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Discontinuation of inhaled corticosteroids in COPD and the risk reduction of pneumonia

Published in Chest, 2015

Using RAMQ data (1990-2005), we formed a cohort of COPD patients who were new users of ICS. We studied the risk of serious pneumonia event under different exposures to ICS using the nested case-control analysis.

Recommended citation: Samy Suissa, Janie Coulombe, Pierre Ernst (2015). " Discontinuation of inhaled corticosteroids in COPD and the risk reduction of pneumonia " Chest. Vol. 148 (5), p. 1177-1183. https://www.sciencedirect.com/science/article/abs/pii/S0012369215502286

Long-term vitamin K antagonists treatment patterns of Non-Valvular Atrial Fibrillation (NVAF): a population-based cohort study

Published in BMC Cardiovascular Disorders, 2016

Using RAMQ data (2000-2009), we described the patterns of VKA treatment following NVAF diagnosis.

Recommended citation: Christel Renoux, Janie Coulombe, Samy Suissa (2016). " Long-term vitamin K antagonists treatment patterns of Non-Valvular Atrial Fibrillation (NVAF): a population-based cohort study" Blood, BMC Cardiovascular Disorders. Vol. 16 (1), p. 84. https://link.springer.com/article/10.1186/s12872-016-0269-4

The risk of major bleeding with low-molecular-weight-heparins for venous thromboembolism in dialysis patients: the Q-VTE Study

Published in Blood, The Journal of the American Society of Hematology, 2016

Using RAMQ data, we compared the risk of major bleeding among dialysis patients with VTE, between those using low molecular weight heparin as compared to vitamin K antagonists.

Recommended citation: Adi J Klil-Drori, Janie Coulombe, Sharon J Nessim, Vicky Tagalakis (2016). " The risk of major bleeding with low-molecular-weight-heparins for venous thromboembolism in dialysis patients: the Q-VTE Study " Blood, The Journal of the American Society of Hematology. Vol. 128 (22), p. 89. https://ashpublications.org/blood/article/128/22/89/98974/The-Risk-of-Major-Bleeding-with-Low-Molecular

The risk of sepsis with inhaled and oral corticosteroids in patients with COPD

Published in COPD: Journal of Chronic Obstructive Pulmonary Disease, 2017

Using RAMQ data (1990 to 2007), we studied the risk of sepsis in COPD patients, under different exposures to inhaled or oral corticosteroids separately.

Recommended citation: Pierre Ernst, Janie Coulombe, Paul Brassard, Samy Suissa (2017). " The risk of sepsis with inhaled and oral corticosteroids in patients with COPD " COPD: Journal of Chronic Obstructive Pulmonary Disease. Vol. 14 (2), p. 137-142. https://www.tandfonline.com/doi/abs/10.1080/15412555.2016.1238450

Revisiting sex differences in outcomes in non-valvular atrial fibrillation: a population-based cohort study

Published in European Heart Journal, 2017

Using the RAMQ data, we studied the risk of ischaemic stroke in NVAF patients and compared it across sex, using a more accurate adjustment for confounding via time-dependent definitions for the confounders.

Recommended citation: Christel Renoux, Janie Coulombe, Samy Suissa (2017). " Revisiting sex differences in outcomes in non-valvular atrial fibrillation: a population-based cohort study " European Heart Journal. Vol. 38 (19), p. 1473-1479. https://academic.oup.com/eurheartj/article/38/19/1473/2884298

Trends in epidemiology of pediatric inflammatory bowel disease in Canada: distributed network analysis of multiple population-based provincial health administrative databases

Published in The American journal of gastroenterology, 2017

Using administrative data from across several Canadian provinces, we conducted a distributed network analysis to study the incidence and prevalence of pediatric-onset IBD and trends of onset over time.

Recommended citation: Eric I Benchimol, Charles N Bernstein, Alain Bitton, Matthew W Carroll, Harminder Singh, Anthony R Otley, Maria Vutcovici, Wael El-Matary, Geoffrey C Nguyen, Anne M Griffiths, David R Mack, Kevan Jacobson, Nassim Mojaverian, Divine Tanyingoh, Yunsong Cui, Zoann J Nugent, Janie Coulombe, Laura E Targownik, Jennifer L Jones, Desmond Leddin, Sanjay K Murthy, Gilaad G Kaplan (2017). " Trends in epidemiology of pediatric inflammatory bowel disease in Canada: distributed network analysis of multiple population-based provincial health administrative databases " The American journal of gastroenterology. Vol. 112 (7), p. 1120. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527278/

Drospirenone-containing oral contraceptive pills and the risk of venous thromboembolism: an assessment of risk in first-time users and restarters

Published in Drug Safety, 2017

Using CPRD data in the UK, we studied the risk of VTE among first-time users of drospirenone-containing COCs.

Recommended citation: Natasha Larivée, Samy Suissa, Janie Coulombe, Vicky Tagalakis, Kristian B Filion (2017). " Drospirenone-containing oral contraceptive pills and the risk of venous thromboembolism: an assessment of risk in first-time users and restarters " Drug Safety. Vol. 40 (7), p. 583-596. https://link.springer.com/article/10.1007/s40264-017-0525-2

Altered cerebellar biochemical profiles in infants born prematurely

Published in Scientific Reports, 2017

We compared the cerebellar biochemical profiles in preterm infants and full-term newbords using 1 H-MRS. We studied associations between altered cerebellar metabolite profiles and brain injury topography, the severity of injury and clinical complications related to prematurity.

Recommended citation: Marie Brossard-Racine, Jonathan Murnick, Marine Bouyssi-Kobar, Janie Coulombe, Taeun Chang, Catherine Limperopoulos (2017). " Altered cerebellar biochemical profiles in infants born prematurely " Scientific Reports. Vol. 7 (1), p. 1-7. https://www.nature.com/articles/s41598-017-08195-4

Pneumonia risk in asthma patients using inhaled corticosteroids: a quasi‐cohort study

Published in British journal of clinical pharmacology, 2017

Using RAMQ data, we built a cohort of asthma patients. We studied the effect of different exposures to ICS (dose/type) on the risks of pneumonia.

Recommended citation: Christina J Qian, Janie Coulombe, Samy Suissa, Pierre Ernst (2017). " Pneumonia risk in asthma patients using inhaled corticosteroids: a quasi‐cohort study" British journal of clinical pharmacology. Vol. 83 (9), p. 2077-2086. https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.13295

Confounding by pre-morbid functional status in studies of apparent sex differences in severity and outcome of stroke

Published in Stroke, 2017

Using a prospective population-based cohort of stroke and transient ischemic attacks, we compared the modified Rankin Scale score (mRS) and the change in mRS prior to and after an event of interest, between men and women.

Recommended citation: Christel Renoux, Janie Coulombe, Linxin Li, Aravind Ganesh, Louise Silver, and Peter M Rothwell (2017). " Confounding by pre-morbid functional status in studies of apparent sex differences in severity and outcome of stroke" Stroke. Vol. 48 (10), p. 2731-2738. https://www.ahajournals.org/doi/full/10.1161/STROKEAHA.117.018187

Patterns of long‐term use of non‐vitamin K antagonist oral anticoagulants for non‐valvular atrial fibrillation: Quebec observational study

Published in Pharmacoepidemiology and Drug Safety, 2017

Using RAMQ data, we studied predictors of long-term use of NOACs in patients with NVAF.

Recommended citation: Antonios Douros, Christel Renoux, Janie Coulombe, Samy Suissa (2017). " Patterns of long‐term use of non‐vitamin K antagonist oral anticoagulants for non‐valvular atrial fibrillation: Quebec observational study" Pharmacoepidemiology and Drug Safety. Vol. 26 (12), p. 1546-1554. https://onlinelibrary.wiley.com/doi/abs/10.1002/pds.4333

Comparative effectiveness of novel oral anticoagulants in UK patients with non-valvular atrial fibrillation and chronic kidney disease: a matched cohort study

Published in BMJ open, 2018

Using CPRD data, we were interested in evaluating the effectiveness and safety of NOACs compared with VKAs in patients with non-valvular atrila fibrillation, with a focus on patients with CKD.

Recommended citation: Simone Y. Loo, Janie Coulombe, Sophie Dell’Aniello, James M Brophy, Samy Suissa, and Christel Renoux (2018). " Comparative effectiveness of novel oral anticoagulants in UK patients with non-valvular atrial fibrillation and chronic kidney disease: a matched cohort study" BMJ open. Vol. 8 (1). https://bmjopen.bmj.com/content/8/1/e019638.abstract

Temporal trends in outpatient management of incident pulmonary embolism and associated mortality

Published in Thrombosis Research, 2018

Using RAMQ data, we studied the trend in outpatient management, and the mortality associated with incidence pulmonary embolism.

Recommended citation: Adi J Klil-Drori, Janie Coulombe, Samy Suissa, Andrew Hirsch, and Vicky Tagalakis (2018). " Temporal trends in outpatient management of incident pulmonary embolism and associated mortality" Thombosis Research. Vol. 161, p. 111-116. https://www.sciencedirect.com/science/article/abs/pii/S004938481730542X

Long-term use of inhaled corticosteroids in COPD and the risk of fracture

Published in CHEST, 2018

Using RAMQ data, we studied the risk of fracture under long-term exposure to inhaled corticosteroids in patients with COPD.

Recommended citation: Anne V. Gonzalez, Janie Coulombe, Pierre Ernst, and Samy Suissa (2018). "Long-term use of inhaled corticosteroids in COPD and the risk of fracture " CHEST. Vol. 153 (2), p. 321-328. https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.1733

Core‐binding factor acute myeloid leukemia with t (8; 21): Risk factors and a novel scoring system (I‐CBF it)

Published in Cancer Medicine, 2018

We constructed a scoring system for predicting who is at higher risk of relapse in patients with CBF AML</i>.

Recommended citation: Celalettin Ustun, Elizabeth Morgan, Erica E. M. Moodie, et al. (2018). "Core‐binding factor acute myeloid leukemia with t (8; 21): Risk factors and a novel scoring system (I‐CBF it) " Cancer Medicine. Vol. 7(9), p. 4447-4455. https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.1733

Weighted regression analysis to correct for informative monitoring times and confounders in longitudinal studies

Published in Biometrics, 2020

We propose two flexible estimators for the marginal effect of a binary intervention on a continuous longitudinal outcome in settings subject to informative monitoring times and confounding.

Recommended citation: Janie Coulombe , Erica EM Moodie, and Robert W Platt. (2020). "Weighted regression analysis to correct for informative monitoring times and confounders in longitudinal studies." Biometrics. 77(1), pp. 162-174. https://onlinelibrary.wiley.com/doi/abs/10.1111/biom.13285

Can the risk of severe depression-related outcomes be reduced by tailoring the antidepressant therapy to patient characteristics?

Published in American Journal of Epidemiology, 2020

We use dynamic weighted survival modelling (DWSurv) as proposed by Simoneau et al. (2020) to develop an optimal adaptive treatment strategy for choosing between two commonly used antidepressant drugs in patients with depression.

Recommended citation: Janie Coulombe , Erica EM Moodie, Susan M Shortreed, and Christel Renoux. (2020). " Can the risk of severe depression-related outcomes be reduced by tailoring the antidepressant therapy to patient characteristics? ." American Journal of Epidemiology. 190(7), pp. 1210-1219. https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwaa260/6028714?redirectedFrom=fulltext

Response to: Baby Steps to a Learning Mental Health Care System: Can we do the Work?

Published in American Journal of Epidemiology, 2020

We provide a response to the commentary by Drs. Shiner and Watts on our previous manuscript Can the risk of severe depression-related outcomes be reduced by tailoring the antidepressant therapy to patient characteristics? .

Recommended citation: Janie Coulombe , Erica EM Moodie, Susan M. Shortreed, and Christel Renoux. (2020). "Response to: Baby Steps to a Learning Mental Health Care System: Can we do the Work?" American Journal of Epidemiology. 190(7), pp. 1223-1224. https://academic.oup.com/aje/advance-article-abstract/doi/10.1093/aje/kwaa262/6028712

Estimating the Marginal Effect of a Continuous Exposure on an Ordinal Outcome using Data Subject to Covariate-Driven Treatment and Visit Processes

Published in Statistics in Medicine, 2021

We extend previous work (Coulombe et al., 2020, Biometrics) to the setting where the outcome is ordinal and the exposure is continuous using a generalized IPT weight and a proportional odds model. We estimate the causal marginal OR for the continuous exposure on the ordinal outcome.

Recommended citation: Janie Coulombe , Erica EM Moodie, and Robert W Platt. (2021). " Estimating the Marginal Effect of a Continuous Exposure on an Ordinal Outcome using Data Subject to Covariate-Driven Treatment and Visit Processes." Statistics in Medicine . In press.

Estimation of the Marginal Effect of Antidepressants on Body Mass Index under Confounding and Endogenous Covariate-Driven Monitoring Times

Published in Annals of Applied Statistics, 2021

We tackle estimation of the marginal effect of a binary exposure in settings where the covariate process interacts with monitoring times all throughout follow-up time (we call “endogenous” such process). We also depict via several causal diagrams the biasing paths caused by covariate-driven monitoring times.

Recommended citation: Janie Coulombe , Erica EM Moodie, Robert W Platt, and Christel Renoux. (2021). " Estimation of the Marginal Effect of Antidepressants on Body Mass Index under Confounding and Endogenous Covariate-Driven Monitoring Times ." Annals of Applied Statistics , forthcoming (accepted on Nov. 9, 2021).

Intraoperative phlebotomies and bleeding in liver transplantation: a historical cohort study and causal analysis

Published in Canadian Journal of Anesthesia, 2022

Recommended citation: François Martin Carrier, Steve Ferreira Guerra, Janie Coulombe, Eva Amzallag, Luc Massicotte, Michaël Chassé, and Helen Trottier. (2022). " Intraoperative phlebotomies and bleeding in liver transplantation: a historical cohort study and causal analysis ." Canadian Journal of Anesthesia , forthcoming.

Privacy-preserving estimation of an optimal individualized treatment rule: a case study in maximizing time to severe depression-related outcomes

Published in Lifetime Data Analysis, 2022

Recommended citation: Erica EM Moodie, Janie Coulombe, Coraline Danieli, Christel Renoux, and Susan M. Shortreed. (2022). " Privacy-preserving estimation of an optimal individualized treatment rule: a case study in maximizing time to severe depression-related outcomes ." Lifetime Data Analysis , forthcoming.